A Rare Case of Aggressive Histiocytic Sarcoma in a 9- years old male Child: Case report and Literature review

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Published: Apr 20, 2023
DOI: https://doi.org/10.57181/ijcrst/vol9i04/61
Keywords:
Histiocytic Sarcoma, Non-Langerhans histiocytes, Chest CT scan, Immunohistochemistry, Aggressive disease, CHOP regimen

Main Article Content

Abel Tadesse
Department of Pediatrics and Child Health, Addis Ababa University
Gashaw Arega
Department of Pediatrics and Child Health, Addis Ababa University,
Daniel Hailu
mulualeme Nigusie
Department of Pediatrics and Child Health, Addis Ababa University,
Getasew Fikad
Department of Pediatrics and Child Health, Addis Ababa University,
Hanna Getachew
Pediatric Surgery Unit, Department of Surgery, Addis Ababa University, Ethiopia
Woubedel Kiflu
Pediatric Surgery Unit, Department of Surgery, Addis Ababa University, Ethiopia
Yodit Semere
Pediatric Surgery Unit, Department of Surgery, Addis Ababa University, Ethiopia
Samuel Sisay
Pediatrics Radiology Unit, Department of Radiology, Addis Ababa University,
Abrehet Zeray
Pediatrics Radiology Unit, Department of Radiology, Addis Ababa University
Mesfin Asefa
Department of Pathology, St Paul Millennium Medical College,
Fitsum Dagmawi
Pediatrician and Child Health Specialist at Bethzatha General Hospital,
Kalkidan Tesfaye
Department of Pediatrics and Child Health, Addis Ababa University
Abdulkadir Mohamedsaid
Department of Pediatrics and Child Health, Addis Ababa University

Abstract

Histiocytic Sarcoma(HS) is an extremely rare non-Langerhans neoplasm primarily composed of malignant cells with morphologically and immunohistochemically showing features of mature tissue histiocytes. It can affect any part of the body with unknown etiology and is an aggressive disease with a worse prognosis and management often requires multimodal treatment.


Here, we report a 9 year old boy who was diagnosed with histiocytic sarcoma after he presented with left-side chest pain, dry cough, and significant weight loss of four months duration. Contrast-enhanced chest CT scan shows a heterogeneous contrast-enhancing solid extra parenchymal mass lesion that appears to be attached to the posteromedial basal pleura with adjacent lung subsegmental collapse and a minimal amount of ipsilateral pleural effusion. There was no evidence of systemic arterial supply. The patient underwent left posterolateral thoracotomy and mass excision. The biopsy and immunohistochemical examination confirmed the diagnosis of Histiocytic Sarcoma. The mass recurred after a month, and he started systemic chemotherapy with a CHOP regimen. Despite the multimodal treatment, he had a progressive disease with multiorgan involvement and was put on palliative care.

Article Details

How to Cite
Tadesse, A., Arega, G., Hailu, D., Nigusie, mulualeme, Fikad, G., Getachew, H., Kiflu, W., Semere, Y., Sisay, S., Zeray, A., Asefa, M., Dagmawi, F., Tesfaye, K. and Mohamedsaid, A. (2023) “A Rare Case of Aggressive Histiocytic Sarcoma in a 9- years old male Child: : Case report and Literature review ”, International Journal of Current Research in Science and Technology, 9(04), pp. 17–22. doi: 10.57181/ijcrst/vol9i04/61.
Issue
Vol. 9 No. 04 (2023): IJCRST: APRIL 2023
Section
Health Science

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