Effect of Dietary modification and regular physical exercise on liver function tests in Patients with Non-alcoholic Fatty Liver Disease

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) describes a spectrum of clinicopathological changes in liver extending from simple steatosis through non-alcoholic steatohepatitis (NASH) to fibrosis. NAFLD is an increasingly prevalent disease, there is a lack of approved therapies for it. Dietary modification and regular physical activities help in weight reduction, which is main principle of treatment in fatty liver diseases.

Objectives: To evaluate the efficacy of exercise and reduction of fatty food intake in NAFLD patients.

Methods: This was sixmonths randomized open level clinical trial. Study was done in Department of Hepatology BSMMU from June 2017 to September 2018.50 patients with sonographic evidence of Fatty liver, who fitted the inclusion & exclusion criteria were enrolled by lottery method. All the included patients were advised to do regular physical exercise and diet restrictions. The liver function tests were done in all patients. After six months of follow up patients underwent biochemical tests of liver function test again in follow up. All data was presented as mean ± SD & analyzed by SPSS (version 23). Qualitative data was analyzed by Chi-square test & quantitative data was analyzed by student’s t-test. A statistically significant result was considered when P value was less than 0.05.

Results: In Comparative analysis of anthropometric, biochemical; ALT, AST, GGT improvement was observed but the improvement was not statistically significant.

Conclusion: Supplementation of pharmacological therapy should be added with non pharmacological therapy in patients with NAFLD to achieve improvement of liver function test.